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Remote monitoring and evaluation of pulmonary diseases via telemedicine are important to disease diagnosis and management, but current telemedicine solutions have limited capability of objectively examining the airway's internal physiological conditions that are crucial to pulmonary disease evaluation. Existing solutions based on smartphone sensing are also limited to externally monitoring breath rates, respiratory events, or lung function. In this paper, we present PTEase, a new system design that addresses these limitations and uses commodity smartphones to examine the airway's internal physiological conditions. PTEase uses active acoustic sensing to measure the internal changes of lower airway caliber, and then leverages machine learning to analyze the sensory data for pulmonary disease evaluation. We implemented PTEase as a smartphone app, and verified its measurement error in lab-controlled settings as <10%. Clinical studies further showed that PTEase reaches 75% accuracy on disease prediction and 11%-15% errors in estimating lung function indices. Given that such accuracy is comparable with that in clinical practice using spirometry, PTEase can be reliably used as an assistive telemedicine tool for disease evaluation and monitoring. 

Pulmonary diseases, such as asthma and Chronic Obstructive Pulmonary Disease (COPD), constitute a major public health challenge. The disease symptoms, including airway obstruction and inflammation, usually result in changes in airway mechanical properties, such as the caliber and impedance of the airway. To measure such airway properties for disease evaluation and diagnosis purposes, pulmonary function tests (PFT) has been widely adopted. However, most existing PFT systems require expensive and cumbersome hardware that are impossible to be used out of clinic. To allow out-clinic continuous pulmonary disease evaluation, in this paper we present AWARE, a new sensing and AI system that supports accurate and reliable PFT using commodity smartphones. AWARE uses a smartphone to transmit acoustic signals and reconstructs the profile of human airway based on the analysis of reflected acoustic waves captured from the smartphone's microphone. The subject's pulmonary condition is then evaluated by a multi-task learning model that integrates both the airway measurements and the subject's lung function records as the ground truth. Evaluations on 75 human subjects demonstrate that AWARE has the capability to achieve 80% accuracy on distinguishing between humans with healthy pulmonary function and with asthma symptoms. 

Abstract For the past 4 years, four different cohorts of students from the Science and Technology program at Eleanor Roosevelt High School in Greenbelt, Maryland, have performed their senior research projects at the Howard University Beltsville Research Campus in Beltsville, Maryland. The projects have focused generally on the testing and correction of low-cost sensors and development of instrumentation for use in profiling the lower atmosphere. Specifically, we have developed a low-cost tethersonde system and used it to carry aloft a low-cost instrument that measures particulate matter (PM) as well as a standard radiosonde measuring temperature, pressure, and relative humidity. The low-cost PM sensor was found to provide artificially high values of PM under conditions of elevated relative humidity, likely due to the presence of hygroscopic aerosols. Reference measurements of PM were used to develop a correction technique for the low-cost PM sensor. Profiling measurements of temperature and PM during the breakdown of a nocturnal inversion were performed using the tethersonde system on 30 August 2019. The evolution of temperature during the breakdown of the inversion was studied and compared with model forecasts. The attempt to measure PM during the tethersonde experiment was not successful, we believe, due to the packaging of the low-cost sensor. Future cohorts of students from Eleanor Roosevelt High School students will work on improving the instrumentation and measurements shown here as we continue the collaboration between the Howard University Beltsville Campus and the local school system. 

CYBERSECURITY AND LOCAL GOVERNMENT Learn to secure your local government’s networks with this one-of-a-kind resource In Cybersecurity and Local Government, a distinguished team of researchers delivers an insightful exploration of cybersecurity at the level of local government. The book makes a compelling argument that every local government official, elected or otherwise, must be reasonably knowledgeable about cybersecurity concepts and provide appropriate support for it within their governments. It also lays out a straightforward roadmap to achieving those objectives, from an overview of cybersecurity definitions to descriptions of the most common security challenges faced by local governments. The accomplished authors specifically address the recent surge in ransomware attacks and how they might affect local governments, along with advice as to how to avoid and respond to these threats. They also discuss the cybersecurity law, cybersecurity policies that local government should adopt, the future of cybersecurity, challenges posed by Internet of Things, and much more. Throughout, the authors provide relevant field examples, case studies of actual local governments, and examples of policies to guide readers in their own application of the concepts discussed within. Cybersecurity and Local Government also offers: A thorough introduction to cybersecurity generally, including definitions of key cybersecurity terms and a high-level overview of the subject for non-technologists. A comprehensive exploration of critical information for local elected and top appointed officials, including the typical frequencies and types of cyberattacks. Practical discussions of the current state of local government cybersecurity, with a review of relevant literature from 2000 to 2021. In-depth examinations of operational cybersecurity policies, procedures and practices, with recommended best practices. Perfect for local elected and top appointed officials and staff as well as local citizens, Cybersecurity and Local Government will also earn a place in the libraries of those studying or working in local government with an interest in cybersecurity. 

Lichens collected worldwide for centuries have resulted in millions of specimens deposited in herbaria that offer the potential to assess species boundaries, phenotypic diversification, ecology, and distribution. The application of molecular approaches to historical collections has been limited due to DNA fragmentation, but high-throughput sequencing offers an opportunity to overcome this barrier. Here, we combined a large dataset of ITS sequences from recently collected material and historical collections, obtained through Sanger, 454, or Illumina Sequencing, to test the performance of ITS barcoding in two genera of lichenized Basidiomycota: Cora and Corella. We attempted to generate new sequence data for 62 fresh specimens (from 2016) and 274 historical collections (collected between 1888 and 1998), for a final dataset of 1325 sequences. We compared various quantitative approaches to delimit species (GMYC, bPTP, ASAP, ABGD) and tested the resolution and accuracy of the ITS fungal barcoding marker by comparison with a six-marker dataset. Finally, we quantitatively compared phylogenetic and phenotypic species delimitation for 87 selected Cora species that have been formally described. Our HTS approach successfully generated ITS sequences for 76% of the historical collections, and our results show that an integrative approach is the gold-standard for understanding diversity in this group. 

Abstract Prokaryotic genomes are often considered to be mosaics of genes that do not necessarily share the same evolutionary history due to widespread horizontal gene transfers (HGTs). Consequently, representing evolutionary relationships of prokaryotes as bifurcating trees has long been controversial. However, studies reporting conflicts among gene trees derived from phylogenomic data sets have shown that these conflicts can be the result of artifacts or evolutionary processes other than HGT, such as incomplete lineage sorting, low phylogenetic signal, and systematic errors due to substitution model misspecification. Here, we present the results of an extensive exploration of phylogenetic conflicts in the cyanobacterial order Nostocales, for which previous studies have inferred strongly supported conflicting relationships when using different concatenated phylogenomic data sets. We found that most of these conflicts are concentrated in deep clusters of short internodes of the Nostocales phylogeny, where the great majority of individual genes have low resolving power. We then inferred phylogenetic networks to detect HGT events while also accounting for incomplete lineage sorting. Our results indicate that most conflicts among gene trees are likely due to incomplete lineage sorting linked to an ancient rapid radiation, rather than to HGTs. Moreover, the short internodes of this radiation fit the expectations of the anomaly zone, i.e., a region of the tree parameter space where a species tree is discordant with its most likely gene tree. We demonstrated that concatenation of different sets of loci can recover up to 17 distinct and well-supported relationships within the putative anomaly zone of Nostocales, corresponding to the observed conflicts among well-supported trees based on concatenated data sets from previous studies. Our findings highlight the important role of rapid radiations as a potential cause of strongly conflicting phylogenetic relationships when using phylogenomic data sets of bacteria. We propose that polytomies may be the most appropriate phylogenetic representation of these rapid radiations that are part of anomaly zones, especially when all possible genomic markers have been considered to infer these phylogenies. [Anomaly zone; bacteria; horizontal gene transfer; incomplete lineage sorting; Nostocales; phylogenomic conflict; rapid radiation; Rhizonema.] 

We explore shadow information technology (IT) at institutions of higher education through a two-tiered approach involving a detailed case study and comprehensive survey of IT professionals. In its many forms, shadow IT is the software or hardware present in a computer system or network that lies outside the typical review process of the responsible IT unit. We carry out a case study of an internally built legacy grants management system at the University of Maryland, Baltimore County that exemplifies the vulnerabilities, including cross-site scripting and SQL injection, typical of such unauthorized and ad-hoc software. We also conduct a survey of IT professionals at universities, colleges, and community colleges that reveals new and actionable information regarding the prevalence, usage patterns, types, benefits, and risks of shadow IT at their respective institutions. Further, we propose a security-based profile of shadow IT, involving a subset of elements from existing shadow IT taxonomies, which categorizes shadow IT from a security perspective. Based on this profile, survey respondents identified the predominant form of shadow IT at their institutions, revealing close similarities to findings from our case study. Through this work, we are the first to identify possible susceptibility factors associated with the occurrence of shadow IT related security incidents within academic institutions. Correlations of significance include the presence of certain graduate schools, the level of decentralization of the IT department, the types of shadow IT present, the percentage of security violations related to shadow IT, and the institution's overall attitude toward shadow IT. The combined elements of our case study, profile, and survey provide the first multifaceted view of shadow IT security at academic institutions, highlighting tension between its risks and benefits, and suggesting strategies for managing it successfully. 

Although technology vendors prefer customers use their products according to pre-planned use cases, incorporating misleading user interfaces and crafting questionable decision points for users can induce them to make low-information decisions that may adversely impact their cybersecurity operational postures.